Our team combines diverse and complementary skills ranging from molecular and cellular microbiology to genomics, bioinformatics and artificial intelligence. We set up multidisciplinary approaches in order to characterize in depth bacteriophages, viruses of bacteria, that exhibit multiple and fascinating aspects and are also promising therapeutic agents.
Our research is organized around three main goals:
i. Phage / bacteria coevolution and regulatory interactions
ii. Phage diversity, genomics and taxonomy
iii. Phages as diagnostic and biocontrol tools
Our group is a founding and active member of the Phages.fr network which allows us to be part of the evolution of our research field and promote new collaborations. We are also involved in Microbiology education at Aix-Marseille Université as well as in multiple science dissemination events.
We host trainees from all education levels, feel free to contact us to join this dynamic and exciting research field!
Mireille Ansaldi était l’invitée de la Fondation evertéa (fondationevertea.org) en Novembre 2024, la vidéo de sa conférence grand public est maintenant en ligne: https://www.youtube.com/watch?v=nrlHXQy9BdE
Bienvenue à : Mélanie Matveeva, en stage de Master 2 Biologie Santé, Maladies infectieuses et microbiote qui contribuera au projet Synergie Phage-antibiotique avec Mireille, Lili
HieVi: protein Large Language Model for proteome-based phage clustering From S. Panigrahi, M. Ansaldi & N. Ginet The “Phage Cycle and Bacterial Metabolism” team at
Our team is happy to host 2 new members : Swapnesh Panigrahi, former member of the IAM team who joined the Phage task force to
Félicitations à Julián Bulssico qui a reçu le Prix de Thèse de la Société Française de Virologie lors des dernières Journées Francophones de Virologie à
Are you interested in Microbiology? Do you want to experience the day-to-day life of a scientist and/or an engineer in an academic laboratory? Do you
On 6/07 Naoual defended her thesis on Appy, a regulator of phage origin with a bi-functional role in host physiology. This was the end of
Découvrez notre premier episode des Chroniques Microbiennes ! Considérés comme l’entité biologique prédominante sur Terre, découvrez les bactériophages, ces virus de bactérie. Le monde microbien reste
Research in this axis focuses on the integration of (pro)phage proteins into the bacterial regulatory network, allowing them to either take control of the host in order to multiply in the case of virulent phages, or, on the contrary, to confer a selective advantage when considering prophage-encoded regulators.
Legend : Tracking infection with fluorescent phages
Legend : Phages@LCBLegend : Host-prophages interactions
Phages are at heart of the genomic “dark matter”. We wish to increase the knowledge on phages to enrich the databases and to discover new functions. Part of our work consists in isolating new phages and characterizing them at the infectious and genomic levels, which opens the way to further molecular studies.
Legend : Mixed plaques of phagesLegend : Phage bouquet
Legend : Siphophage kiss
Antibiotic-resistant strains makes phages a weapon of choice in the fight against bacterial infections. We work on the therapeutic potential of phages in combination with antibiotics at the single-cell level. We also develop biocontrol and diagnostics tools to control bacterial infections.
Legend : Phage DNA injection caught in the act
Legend : Pills of phages (credit: Eliza Wolfson @eliza_coli)
Group leader / Research director (DR-CNRS)
Researcher (CR-CNRS)
Research engineer (IR-CNRS)
Researcher (CDD-AMU)
PhD student (PhD-AMU)
Trainee (Master 2)
Trainee (Master 2)
